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Cancer's Magic Bullet - AHFMR Magazine March/April 1999
AHFMR Magazine - Mar/Apr 1999


Dr. Patrick Lee A virus is a parasite that, in order to replicate, must first attach itself to a cell and then find a way to enter it. When a virus emerges from a targeted cell, it will have replicated itself a thousand-fold. Heritage-funded cancer researcher Dr. Patrick Lee has discovered that a particular virus called reovirus can replicate only in cells with a highly active biochemical pathway called the Ras signalling pathway. It's an important finding, because an active Ras signalling pathway is found in many cancer cells.

The reovirus appears to be very effective against a number of cancers. Tests on mice that have implanted human brain and breast cancer tumours have dramatically demonstrated this potential. Dr. Lee has shown that injecting live reovirus into these tumours results in the virus's replicating and killing the cancer cells. The reovirus technology is proving to be effective in mice against 80% of cancers, including pancreatic, prostate, and breast cancer, as well as brain tumours.


Dr. Patrick Lee is supported through AHFMR's Technology Commercialization Program. He receives additional funding from the Medical Research Council of Canada and the Alberta Cancer Board. Dr. Lee is a Professor of Cancer Biology in the Department of Microbiology and Infectious Diseases in the Faculty of Medicine at the University of Calgary.

Quick Reference of Contents:
AHFMR in the Community | Ask Jacques | SEARCH Profile
Sexual Well-Being After Cancer | Exercise and Cancer
Cancer and the Immune System | Two Sides of a Gene
Better Breast Cancer Screenings | An Age-Old Battle
Cancer's Magic Bullet | Pumping Up the Volume